Late persistent infections

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If Lyme disease is not promptly or effectively treated, damage to the joints, nerves, and brain may develop months or years after you become infected (late Lyme disease).

Symptoms at this stage may include:
-Swelling and pain (inflammation) in the joints, especially in the knees.
-Numbness and tingling in the hands, feet, or back.
-Severe fatigue.
-Partial facial nerve paralysis (Bell's palsy), which usually occurs within the first few months after the tick bite.
-Neurologic changes, including problems with memory, mood, or sleep, and sometimes problems speaking.
-Chronic Lyme arthritis, which causes recurring episodes of swelling, redness, and fluid buildup in one or more joints that last up to 6 months at a time.
-Heart, nervous system, and joint symptoms may be the first signs of Lyme disease in people who did not have a rash or other symptoms of early infection.